| human | 遺伝子名 | sialoadhesin |
| 同義語(エイリアス) | Sialic acid-binding Ig-like lectin-1; SIGLEC-1; CD169; DKFZp667F058; Sialoadhesin precursor; CD169 antigen; FLJ00073; SIGLEC1; FLJ00411; FLJ00051; FLJ32150; SN; dJ1009E24.1; sialic acid binding Ig-like lectin 1, sialoadhesin; Siglec-1; FLJ00055 | |
| SWISS-PROTのID | SWISS-PROT:Q9BZZ2 | |
| EntrezGeneのID | EntrezGene:6614 | |
| その他のDBのID | HGNC:11127 |
本文中に表示されているデータベースの説明
出典:Wiktionary
sialoadhesin (countable かつ uncountable, 複数形 sialoadhesins)
出典:Wikipedia
出典:『Wikipedia』 (2011/04/15 05:17 UTC 版)
Sialoadhesin is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. It is found in especially high amounts on macrophages of the spleen, liver, lymph node, bone marrow, colon, and lungs. Also, in patients suffering from rheumatoid arthritis, the protein has been found in great amounts on macrophages of the affected tissues. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Sialoadhesin binds to certain molecules called sialic acids. During this binding process a salt bridge (protein) is formed between a highly conserved arginine residue (from the v-set domain to the 3'-sialyllactose) and the carboxylate group of the sialic acid. Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169).