| human | 遺伝子名 | Urocortin II |
| 同義語(エイリアス) | UCN2; Urocortin-2 precursor; Stresscopin-related peptide; UCNI; urocortin 2; SRP; Urocortin-related peptide; Ucn II; UCN-II | |
| SWISS-PROTのID | SWISS-PROT:Q96RP3 | |
| EntrezGeneのID | EntrezGene:90226 | |
| その他のDBのID | HGNC:18414 |
| mouse | 遺伝子名 | Urocortin II |
| 同義語(エイリアス) | Urocortin-2 precursor; Ucn-2; Ucn2; Ucn II; urocortin 2 | |
| SWISS-PROTのID | SWISS-PROT:Q99ML8 | |
| EntrezGeneのID | EntrezGene:171530 | |
| その他のDBのID | MGI:2176375 |
| rat | 遺伝子名 | Urocortin II |
| 同義語(エイリアス) | urocortin 3; Urocortin-2 precursor; Ucn3; Ucn2; Ucn II; urocortin 2 | |
| SWISS-PROTのID | SWISS-PROT:Q91WW1 | |
| EntrezGeneのID | EntrezGene:170896 | |
| その他のDBのID | RGD:620765 |
本文中に表示されているデータベースの説明
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出典:Wikipedia
出典:『Wikipedia』 (2011/05/23 15:36 UTC 版)
Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family. Immunohistochemistry analysis of human myocytes has shown greater immunoreactivity of Ucn2 in myocytes of the failing heart compared to those of the healthy heart. Researchers suggest this is a result of an innate mechanism in which Ucn2 acts to improve function of the failing heart [2]. The pathophysiology of heart failure is often a consequence of improper calcium handling and relaxation resulting in a lower cardiac output, decreased blood flow and overall decreased heart function [3]. Infusion of Ucn2 in healthy humans has shown a dose dependent increase in cardiac output, heart rate and left ventricle ejection fraction and a decrease in systemic vascular resistance [4]. Ucn2 has been studied as potential treatment for individuals with heart failure.