a protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. the gene for bcl2 is found on chromosome 18, and transfer of the bcl2 gene to a different chromosome is seen in many b-cell leukemias and lymphomas. this causes the bcl2 protein to be made in larger amounts, which may keep cancer cells from dying. also called b-cell leukemia/lymphoma 2 protein.
human | 遺伝子名 | BCL 2 |
同義語(エイリアス) | Bcl-2; BCL2; Apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2 | |
SWISS-PROTのID | SWISS-PROT:P10415 | |
EntrezGeneのID | EntrezGene:596 | |
その他のDBのID | HGNC:990 |
mouse | 遺伝子名 | Bcl-2 |
同義語(エイリアス) | D630044D05Rik; AW986256; Apoptosis regulator Bcl-2; C430015F12Rik; B-cell leukemia/lymphoma 2; D830018M01Rik; Bcl2 | |
SWISS-PROTのID | SWISS-PROT:P10417 | |
EntrezGeneのID | EntrezGene:12043 | |
その他のDBのID | MGI:88138 |
rat | 遺伝子名 | Bcl-2 |
同義語(エイリアス) | B cell lymphoma 2 associated oncogene; B-cell leukemia/lymphoma 2; 10229; Apoptosis regulator Bcl-2; Bcl2 | |
SWISS-PROTのID | SWISS-PROT:P49950 | |
EntrezGeneのID | EntrezGene:24224 | |
その他のDBのID | RGD:2199 |
zfish | 遺伝子名 | bcl2 |
同義語(エイリアス) | B-cell leukemia/lymphoma 2 | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:570772 | |
その他のDBのID | ZFIN:ZDB-GENE-051012-1 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/06/28 21:33 UTC 版)
Bcl-2 (B-cell lymphoma 2) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Bcl-2 orthologs have been identified in numerous mammals for which complete genome data are available. The two isoforms of Bcl-2, Isoform 1, also known as 1G5M, and Isoform 2, also known as 1G5O/1GJH, exhibit similar fold. However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms