fly | 遺伝子名 | Calcineurin |
同義語(エイリアス) | CanA14D; CG9842; Pp12-14D; D33; canA; Pp2B-14D; Pp2B-14DF; protein phosphatase from PCR fragment D33; CnnA14D; PpD33; Protein phosphatase D33; Protein phosphatase 2B at 14D; Calmodulin-dependent calcineurin A2 subunit; DmPp2B-14D; calcineurin; PP2B 14D | |
SWISS-PROTのID | SWISS-PROT:Q27889 | |
EntrezGeneのID | EntrezGene:32624 | |
その他のDBのID | FlyBase:FBgn0011826 |
fly | 遺伝子名 | calcineurin |
同義語(エイリアス) | PP2B 21EF; DmCanA1-100B; D14; CnnA21EF; PpD14; pMY4; Calcineurin A1; canA; Can; protein phosphatase from PCR fragment D14; CNA1; Protein phosphatase D14; CAN A1/PP2B; Calmodulin-dependent calcineurin A1 subunit; CanA1; CG1455 | |
SWISS-PROTのID | SWISS-PROT:P48456 | |
EntrezGeneのID | EntrezGene:43670 | |
その他のDBのID | FlyBase:FBgn0010015 |
本文中に表示されているデータベースの説明
出典:Wiktionary
calcineurin (countable かつ uncountable, 複数形 calcineurins)
出典:Wikipedia
出典:『Wikipedia』 (2011/05/15 13:58 UTC 版)
Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and calcium-dependent serine-threonine phosphatase, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes cyclosporine, pimecrolimus and tacrolimus.