a nutrient that that body needs in small amounts to function and stay healthy. retinoic acid is made in the body from vitamin a and helps cells to grow and develop, especially in the embryo. a form of retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). retinoic acid is being studied in the prevention and treatment of other types of cancer. also called all-trans retinoic acid, atra, tretinoin, and vitamin a acid.
身体の機能や健康維持のために少量だけ必要とされる栄養素。レチノイン酸は体内でビタミンaから作られ、特に胚において細胞の発生と増殖に関与する。製造ラボで合成されたレチノイン酸は、にきびなどの疾患を治療するために皮膚に塗って使用されるほか、経口剤として急性前骨髄性白血病(血液および骨髄中に幼若な造血細胞が過剰に存在する増殖の速いがん)の治療に用いられる。レチノイン酸は他の種類のがんに対する予防と治療の分野でも研究されている。「all-trans retinoic acid(全トランス型レチノイン酸)」、「atra」、「tretinoin(トレチノイン)」、「vitamin a acid(ビタミンa酸)」とも呼ばれる。
出典:Wikipedia
出典:『Wikipedia』 (2011/07/04 02:28 UTC 版)
Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals which includes all higher animals from fishes to humans. During early embryonic development, retinoic acid generated in a specific region of the embryo helps determine position along the embryonic anterior/posterior axis by serving as an intercellular signaling molecule that guides development of the posterior portion of the embryo. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages.