Small hairpin RNAとは 意味・読み方・使い方

Provided are small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules, capable of mediating RNA interference (RNAi) against target nucleic acid sequences.例文帳に追加

標的核酸配列に対するＲＮＡ干渉（ＲＮＡｉ）を媒介しうる小核酸分子，例えば，短干渉核酸（ｓｉＮＡ），短干渉ＲＮＡ（ｓｉＲＮＡ），二本鎖ＲＮＡ（ｄｓＲＮＡ），マイクロＲＮＡ（ｍｉＲＮＡ），および短ヘアピンＲＮＡ（ｓｈＲＮＡ）分子。 - 特許庁

To provide a method for designing a small RNA double strand or a hairpin RNA, having high knockdown efficiency not only in a tissue (heart, kidney or the like in human being) highly expressing Ago2 but also in a tissue (liver, pancreas or the like in the human being) slightly expressing the Ago2.例文帳に追加

Ago2の発現が高い組織(ヒトでは心臓や腎臓など)のみならず、Ago2の発現が低い組織(ヒトでは肝臓や膵臓など)においてもノックダウンの効率が高いsmall RNA二本鎖あるいはヘアピン型RNAを設計する方法を提供すること。 - 特許庁

Small nucleic acid molecules mediating RNA interference (RNAi) to the expression and/or activity of VEGF and/or VEGFr gene, including short interfering nucleic acid(siNA), short interfering RNA(siRNA), double-stranded RNA(dsRNA), microRNA(miRNA) and short hairpin RNA(shRNA) molecules, are provided.例文帳に追加

ＶＥＧＦおよび／またはＶＥＧＦｒ遺伝子の発現および／または活性に対するＲＮＡ干渉（ＲＮＡｉ）を媒介しうる小核酸分子，例えば，短干渉核酸（ｓｉＮＡ），短干渉ＲＮＡ（ｓｉＲＮＡ），二本鎖ＲＮＡ（ｄｓＲＮＡ），マイクロＲＮＡ（ｍｉＲＮＡ），および短ヘアピンＲＮＡ（ｓｈＲＮＡ）分子。 - 特許庁