英和和英

to give one trouble―weigh on one's mind

make bitter

to be troubled by something

be in torment

to taste the bitters of life―see hardships

the act of tormenting someone

to be easy―to come natural to one

distressing

slovenliness and dirtiness

to become serious

to be anxious about anything―worried over anything―to worry oneself over anything―trouble oneself about anything―take anything to heart

to struggle in troubled times

of a person, to leave one's suffering

to do one harm

to be worried and undergo hardships

in hot water

the condition of taking great pains

a quality of being distressing

having frets

to turn sharper

hardships

to drain the cup of bitterness to the dregs

to writhe in agony

be in a tight squeeze

the state of being in a difficult situation

to become worse―change for the worse―take a turn for the worse―deteriorate―（食物なら）―Pickles go bad―Eggs spoil―Meat or fish taints―Milk turns sour.

（事なら）to end―come to an end―be finished―be over―（物なら）―run out―be all gone

feel melancholy

the state of being cramped because of being in a narrow place

to experience many hardships