human | 遺伝子名 | Neprilysin |
同義語(エイリアス) | Common acute lymphocytic leukemia antigen; CD10 antigen; EPN; NEP; Enkephalinase; enkephalinase; Neutral endopeptidase 24.11; Neutral endopeptidase; MME; MGC126681; Atriopeptidase; CD10; MGC126707; DKFZp686O16152; CALLA | |
SWISS-PROTのID | SWISS-PROT:P08473 | |
EntrezGeneのID | EntrezGene:4311 | |
その他のDBのID | HGNC:7154 |
mouse | 遺伝子名 | neprilysin |
同義語(エイリアス) | CD10 antigen; neutral endopeptidase; C85356; Atriopeptidase; 6030454K05Rik; CD10; NEP; membrane metallo endopeptidase; Mme; Neprilysin; Enkephalinase; Neutral endopeptidase 24.11; CALLA; Neutral endopeptidase | |
SWISS-PROTのID | SWISS-PROT:Q61391 | |
EntrezGeneのID | EntrezGene:17380 | |
その他のDBのID | MGI:97004 |
rat | 遺伝子名 | Neprilysin |
同義語(エイリアス) | CD10 antigen; Atriopeptidase; MGC93576; NEP; CD10; membrane metallo endopeptidase; 10904; Mme; 10903; Enkephalinase; Neutral endopeptidase 24.11; Nep; Neutral endopeptidase | |
SWISS-PROTのID | SWISS-PROT:P07861 | |
EntrezGeneのID | EntrezGene:24590 | |
その他のDBのID | RGD:3098 |
worm | 遺伝子名 | neprilysin |
同義語(エイリアス) | ZK20.6.2; ZK20.6.1; ZK20.6; nep-1; CE39118; WP:CE39118; Neprilysin-1 | |
SWISS-PROTのID | SWISS-PROT:Q18673 | |
EntrezGeneのID | EntrezGene:174787 | |
その他のDBのID | WormBase:WBGene00013926 |
worm | 遺伝子名 | Neprilysin |
同義語(エイリアス) | F12A10.4; CE01907; WP:CE01907 | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:173933 | |
その他のDBのID | WormBase:WBGene00017393 |
worm | 遺伝子名 | Neprilysin |
同義語(エイリアス) | WP:CE37363; CE37363; F26G1.6 | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:173824 | |
その他のDBのID | WormBase:WBGene00017842 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/05/27 05:47 UTC 版)
Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.