the protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. it is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor. also called egfr, erbb1, and her1.
fly | 遺伝子名 | Epidermal growth factor receptor |
同義語(エイリアス) | c-erbB; d-egf-r; CG10079; DER; EGF-receptor; Torpedo/DER; EGF receptor; C-erb; flb; l(2)57Ea; top; DER-Ellipse; Torpedo; Elp-1; Protein torpedo; torpedo/egfr; Epidermal growth factor receptor precursor; dEGFR1; DER/faint little ball; DER/top; Egf-r; dEGFR; faint little ball; Torpedo/Egfr; top: torpedo; Ellipse torpedo; EGF-R; DER/torpedo; EgfR; Elp-B1; Egf; EGFR; DER flb; epidermal growth factor receptor; DER\torpedo; pnt; EGFr; EGF Receptor; EK2-6; egfr; l(2)57DEFa; flb: faint little ball; D-EGFR; Degfr; l(2)05351; Drosophila relative of ERBB; Ellipse; torpedo/Egfr; Elp; top/flb; Der; l(2)57EFa; Elp-B1RB1; torpedo/DER; DmHD-33; torpedo; DER/EGFR; HD-33; top/DER; l(2)09261; El: Ellipse; D-Egf; Gurken receptor; Egfr | |
SWISS-PROTのID | SWISS-PROT:P04412 | |
EntrezGeneのID | EntrezGene:37455 | |
その他のDBのID | FlyBase:FBgn0003731 |
mouse | 遺伝子名 | epidermal growth factor receptor |
同義語(エイリアス) | wa-2; Erbb; 9030024J15Rik; AI552599; Epidermal growth factor receptor precursor; Egfr; Errp; Wa5; wa2 | |
SWISS-PROTのID | SWISS-PROT:Q01279 | |
EntrezGeneのID | EntrezGene:13649 | |
その他のDBのID | MGI:95294 |
rat | 遺伝子名 | epidermal growth factor receptor |
同義語(エイリアス) | ERBB1; Egfr-related peptide; Egfr; ErbB-1; Errp | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:24329 | |
その他のDBのID | RGD:2543 |
zfish | 遺伝子名 | epidermal growth factor receptor |
同義語(エイリアス) | EGFR12; egfr; EGFR15 | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:378478 | |
その他のDBのID | ZFIN:ZDB-GENE-030918-1 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/05/04 16:47 UTC 版)
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. Epidermal Growth Factor was discovered by Stanley Cohen of Vanderbilt University along with Rita Levi-Montalcini for which both received the Nobel prize in Physiology or Medicine in 1986.