human | 遺伝子名 | prolyl endopeptidase |
同義語(エイリアス) | Post-proline cleaving enzyme; PREP; Prolyl endopeptidase; PE; MGC16060 | |
SWISS-PROTのID | SWISS-PROT:P48147 | |
EntrezGeneのID | EntrezGene:5550 | |
その他のDBのID | HGNC:9358 |
mouse | 遺伝子名 | prolyl endopeptidase |
同義語(エイリアス) | PEP; AI450383; Prep; prolyl oligopeptidase; D10Wsu136e; AI047692; Pep; Post-proline cleaving enzyme; Prolyl endopeptidase; PE | |
SWISS-PROTのID | SWISS-PROT:Q9QUR6 | |
EntrezGeneのID | EntrezGene:19072 | |
その他のDBのID | MGI:1270863 |
rat | 遺伝子名 | prolyl endopeptidase |
同義語(エイリアス) | Prep; rPop | |
SWISS-PROTのID | --- | |
EntrezGeneのID | EntrezGene:83471 | |
その他のDBのID | RGD:620841 |
本文中に表示されているデータベースの説明
出典:Wikipedia
出典:『Wikipedia』 (2011/06/13 00:55 UTC 版)
Prolyl endopeptidase (PREP) or prolyl oligopeptidase, sometimes post-proline cleaving enzyme) is a large cytosolic enzyme that belongs to a distinct class of serine peptidases. It was first described in the cytosol of rabbit brain as an oligopeptidase, which degrades the nonapeptide bradykinin at the Pro-Phe bond. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotensin, neurotensin, oxytocin, substance P and vasopressin. PREP cleaves peptide bonds at the C-terminal side of proline residues. Its activity is confined to action on oligopeptides of less than 10 kD and it has an absolute requirement for the trans-configuration of the peptide bond preceding proline.