Developmental Toxicityとは 意味・読み方・使い方

To provide a simple and versatile method for predicting developmental toxicity possessed by a chemical substance.例文帳に追加

簡便で汎用性の高い化学物質が有する発生毒性の予測方法を提供する。 - 特許庁

(1) Substance for which it is described that clear reproduction toxicity *(excluding small changes in sperm measurement items, incidence of spontaneous defects in fetus, variant/ossification retardation, fetal/pup body weight, and postnatal developmental assessments) is manifested when taken at a dosage which does not indicate general toxicity (not only maternal toxicity, but also effects except for reproduction toxicity on female and male parental animals; the same shall apply hereinafter) in parental animals in animal experiments in the information of Priority 1.例文帳に追加

(1)Priority1 の情報で、動物実験において親動物で一般毒性（母体毒性のみではなく、雌雄の親動物にたいする生殖毒性以外の影響以下同じ）が示されない用量で明確な生殖毒性※（精液の測定項目、胎児の偶発的異常の発生率、変異・化骨遅延、胎児／生後児の体重、生後の発生指標のわずかな変化等を除く）が発現すると記載されている物質 - 経済産業省

In its broadest sense, development toxicity includes any effect which interferes with normal development of the conceptus, either before or after birth. However, for the purpose of classification, developmental toxicity essentially means adverse effects induced during pregnancy, or as a result of parental exposure.例文帳に追加

発生毒性を広義にとらえると、胎盤、胎児あるいは生後の児の正常な発生を妨害するあらゆる作用が含まれるが、分類するという目的のために、発生毒性とは本質的に妊娠中または親の暴露によって誘発される悪影響をいう。 - 経済産業省

(1) Substance for which it is described that clear reproduction toxicity (excluding small changes in sperm measurement items, incidence of spontaneous defects in fetus, variant/ossification retardation, fetal/pup body weight, postal developmental assessments) is manifested when taken at a dosage with which general toxicity in parental animals is manifested in animal experiments.例文帳に追加

(1)動物実験で親動物での一般毒性が発現する用量で明確な生殖毒性（精液の測定項目、胎児の偶発的異常の発生率、変異・化骨遅延、胎児／生後児の体重、生後の発生指標のわずかな変化等を除く）が発現すると記載されている物質 - 経済産業省

(2) Substance for which it is described that clear reproduction toxicity (excluding small changes in sperm measurement items, incidence of spontaneous defects in fetus, variant/ossification retardation, fetal/pup body weight, postal developmental assessments) is manifested, though descriptions regarding general toxicity in parental animals in animal experiments are not available.例文帳に追加

(2) 動物実験で親動物での一般毒性に関する記述がないが、明確な生殖毒性（精液の測定項目、胎児の偶発的異常の発生率、変異・化骨遅延、胎児／生後児の体重、生後の発生指標のわずかな変化等を除く）が発現すると記載されている物質 - 経済産業省

A substance for which it is described that clear reproduction toxicity (excluding small changes in sperm measurement items, incidence of spontaneous defects in fetus, variant/ossification retardation, fetal/pup body weight, postal developmental assessments) is manifested when taken at a dosage with which general toxicity in parental animals is not manifested in animal experiments, in Priority 2 is determined as having no evidence (ground) reliable enough to be classified as Category 1B, and so is classified as Category 2 in this guideline.例文帳に追加

Priority２の情報で、動物実験において親動物での一般毒性が示されない用量で明確な生殖毒性（精液の測定項目、胎児の偶発的異常の発生率、変異・化骨遅延、胎児／生後児の体重、生後の発生指標のわずかな変化等を除く）が発現すと記載されている物質については、区分 1Ｂにするほど確かな証拠（根拠）はないとし、本指針においては区分２と整理する。 - 経済産業省