He went out in spite of the rain.
He went out in spite of the heavy rain.
He arrived on time in spite of the rain.
He was wet to the skin from the rain.
In spite of the storm, he went out.
He went out in spite of the storm.
He was unfortunately caught in a shower.
The rainy weather has depressed him [his spirits].
He was standing out in the rain.
The rain beat down on his umbrella.
He departed in spite of the storm.
He started in spite of the rain.
He said that it might rain.