pemphigus vulgarisとは 意味・読み方・使い方

A prescribed amount of immunocompetent cells such as spleen cells prepared from the nonhuman mammal having the deficiency of the antigen gene of the autoimmune disease is implanted to the nonhuman mammal having the antigen protein to activate the production of an antibody reacting with the antigen protein, or the T-cell, and to produce the objective nonhuman mammal exhibiting the phenotype of the autoimune disease such as the pemphigus vulgaris.例文帳に追加

自己免疫疾患の抗原遺伝子を欠損している非ヒト哺乳動物から調製した脾細胞等の免疫担当細胞の所定量を、抗原タンパク質を有する非ヒト哺乳動物に移植し、かかる抗原タンパク質に反応する抗体の産生又はＴ細胞を活性化させて、尋常性天疱瘡等の自己免疫疾患の表現型を示す非ヒト哺乳動物の作製する。 - 特許庁

To provide a method for creating a nonhuman mammal by which the mammal exhibiting a phenotype of autoimmune disease such as pemphigus vulgaris is created more easily at a short time while not requiring the preparation of an antigen protein such as a recombinant Dsg3 protein, and while omitting a step for immunizing a nonhuman mammal having deficiency of an antigen gene of the autoimmune disease, such as Dsg3^-/- mouse.例文帳に追加

組換えＤｓｇ３タンパク質等の抗原タンパク質の調製を不要とし、かつ、Ｄｓｇ３^-/-マウス等の自己免疫疾患の抗原遺伝子が欠損している非ヒト哺乳動物を免疫するステップを省略することができる、より簡便に短期間で尋常性天疱瘡等の自己免疫疾患の表現型を示す非ヒト哺乳動物を作製する方法を提供すること。 - 特許庁