英和和英

発音

• IPA: /mæb/

接尾辞

-mab

1. (pharmacology) monoclonal antibody

使用する際の注意点

USAN guidelines for non-proprietary names of monoclonal antibodies are as follows:

• an arbitrary prefix to create a unique name (officially monosyllabic)
• a suffix for the disease state
• a suffix for the animal source
• -mab to identify it as a monoclonal antibody (MAb)

The source suffixes are as follows:

-a- for rat-derived,

-e- for hamster,

-i- for primate,

-o- for mouse,

-u- for human,

-xi- for chimeric,

-zu- for humanized,

-xizu- for humanized and chimeric,

-axo- for rat–mouse hybrid.

The disease target suffixes are:

-vir- viral,

-bac- bacterial,

-lim- immune system, immunomodulator,

-les- infectious lesions,

-cir- cardiovascular

-col- colon tumor,

-mel- melanoma,

-mar- mammary tumor,

-got- testicular (gonad) tumor,

-gov- ovarian (gonad) tumor,

-pro- prostate tumor,

-tum- other tumors, or combinations of the above;

-ner- nervous system,

-kin- interleukin,

-mul- musculoskeletal,

-os- bone,

-toxa- toxin,

-fung- fungus

Other attested target affixes are -anibi- and -neur-. The target affix takes the primary stress.

For instance, capromab is a murine MAb that targets prostate cancer; imiciromab pentatate is used to target myocardial infarctions; satumomab pendetide is used for both colorectal and ovarian cancers.

For humanized (-zu-) and chimeric (-xi-) MAbs (and -xizu-), the final consonant of the target suffix is dropped, and for all others the o of -pro- and the a of -toxa- is dropped: natalizumab, a humanized monoclonal antibody used in the treatment of multiple sclerosis (an immunological disease).

派生語

関連する語

• -ab
• -pab for polyclonal antibodies
• -tinib for tyrosine kinase inhibitors

参照

• USP Dictionary of USAN and International Drug Names, U.S. Pharmacopeia, 2000
• AMA (USAN) Monoclonal antibodies, USAN, 2007

アナグラム

• amb., amb, BMA, Bam, MBA, bam, ABM, BAM, B. M. A., Mba

名詞

mab (plural mabs)

1. (obsolete) A slattern.
2. (obsolete) A cab; a hackney.

動詞

mab (third-person singular simple present mabs, present participle mabbing, simple past and past participle mabbed)

1. (obsolete) To dress untidily.

参照

Noah Webster (1828), “mab”, in An American Dictionary of the English Language: […], volume II (J–Z), New York, N.Y.: […] S. Converse; printed by Hezekiah Howe […], →OCLC.

• (cab): John Camden Hotten (1873), The Slang Dictionary
• (cab): 1909, John Stephen Farmer, William Ernest Henley, Slang and Its Analogues Past and Present: "A mab is a jingling jarvey […] "

アナグラム

• amb., amb, BMA, Bam, MBA, bam, ABM, BAM, B. M. A., Mba