“When things are at the worst, they will mend”
Even if you are faced with difficulties, do your best to overcome them.
There's an implication of “in spite of difficulty" in the phrase “manage to win." manage to win
“One calamity follows on the heels of another”
“It may go to the devil for all I care”
We couldn't have sustained such difficulties for long.
Mysterious are the vicissitudes of life.
“A curse cuts both ways”
“A curse cuts both ways”
There may be difficulties, but we will carry on regardless.
These difficulties are enough to discourage―dishearten―daunt―the bravest heart.