つまり疲労困憊、心も体もクタクタです。の英語

That is, total exhaustion. Body and soul completely knackered.

of a body or mind, to become extremely exhausted

physically and mentally fatigued

to pent up negative emotions

a condition of being completely tired in body and mind

Being tired all the time is an indication that you may be sick.

to collapse with exhaustion

to flop down heavily when one is physically tired

I often feel extremely exhausted.

My mental fatigue was terrible.

an enervation of mind greater than any fatigue

My fatigue is building

I always have a tired feeling.

the state of being weak in mind and body

It has a pain relieving effect.

of one's mind or body lacking power and being weak

I think I am tired.

I'm as tired as tired can be.

the degree to which one's physical and/or mental health is unsound

You seem very tired.

You look very tired.

I am tired but I feel good.

The best way to recover from [get over] one's fatigue is to sleep well.

to harden oneself to fatigue

Besides, I was in trouble from injuries caused by many years of fatigue.

That medicine is for recovering from fatigue.

the state of being very tired

That means, "extremely exhausting".

One is more prone to make mistakes when one is tired.

He must be tired.